In a brain with a neurological disorder like epilepsy, synchronization between groups of neurons can grow to a dangerous extent when a collection of brain cells begins to emit excess electricity. Researchers used a mathematical model to explore the interplay between neurons that leads to these transitions in synchronization during the onset of seizures.
In a large-scale study of electronic health records investigators determined the prevalence of functional seizures and characterized comorbidities associated with them. Functional seizures are sudden attacks or spasms that look like epileptic seizures but do not have the aberrant brain electrical patterns of epilepsy. The research team confirmed associations […]
A new study shows that a protein -- called DUSP4 -- was increased in healthy brain tissue directly adjacent to epileptic tissue. The research suggests that boosting levels of DUSP4 could be a novel way of preventing or treating epilepsy.
People with generalized epilepsy who have seizures arising from both sides of the brain simultaneously, have a higher risk of obstructive sleep apnea (OSA) compared to patients who have focal epilepsy where seizures emanate from one area of the brain, according to a Rutgers study.
More frequent seizures during the menstrual cycle in women with genetic generalized epilepsy have been linked for the first time to drug-resistant epilepsy, when anti-seizure medications don't work, according to a new study that may help lead to tailored treatments.
Now a new study has found there is no difference in developmental and behavioral outcomes for children who have febrile seizures after vaccination, children who have febrile seizures not associated with vaccination and children who have never had a seizure.
Researchers have identified a critical new step in how brain cells function in people with one of the most common forms of epilepsy. This could lead to new treatment approaches for people with drug-resistant epilepsy.
A major international study has uncovered three molecules that have the potential to be developed into new drugs to treat epilepsy. The findings are an important step towards discovering new drugs for people with epilepsy whose seizures cannot be controlled with current treatments.
Marking a major milestone on the path to meeting the objectives of the NIH BRAIN initiative, researchers advance high-density electroencephalography (EEG) as the future paradigm for dynamic functional neuroimaging.
Unprovoked recurrent seizures are a serious problem affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Researchers tested the hypothesis that glioma-induces processes that renders a type of brain cells dysfunctional, perpetuating the imbalance between excitation and inhibition in tumor-associated epilepsy […]
Certain forms of epilepsy are accompanied by inflammation of important brain regions. Researchers have now identified a mechanism that explains this link. Their results may also pave the way to new therapeutic options in the medium term.
In patients with epilepsy, normal neurological activity becomes disrupted, causing debilitating seizures. Now, researchers report that they have found a potential new treatment for this disorder by turning to traditional Chinese medicine. Tests of extracts from plants used in these ancient remedies led the team to one compound, derived from a magnolia tree, […]
Epilepsia, Volume 62, Issue 4, Page 984-996, April 2021.
Roberto A. Molina,
Jorge G. Burneo,
Epilepsia, Volume 62, Issue 4, Page 1005-1021, April 2021.
Wim Van Paesschen,
Christian Erich Elger,
Epilepsia, Volume 62, Issue 4, Page 973-983, April 2021.
Epilepsy Phenome/Genome Project, Epi4K Consortium,
Andrew S Allen,
Samuel F Berkovic,
Evan E Eichler,
Michael P Epstein,
David B Goldstein,
Erin L Heinzen,
Michael R Johnson,
Daniel H Lowenstein,
Anthony G Marson,
Heather C Mefford,
Terence J O'Brien,
Elizabeth K Ruzzo,
Ingrid E Scheffer,
Elliott H Sherr,
Samuel F. Berkovic,
Daniel H. Lowenstein,
Paul V. Motika,
Juliann M. Paolicchi,
Jack M. Parent,
Renée A. Shellhaas,
Elliott H. Sherr,
Jerry J. Shih,
Rani K. Singh,
Michael C. Smith,
Eileen P. G. Vining,
Gretchen K. Von Allmen,
Melodie R. Winawer,
Liu Lin Thio,
Researchers show that increased sensitivity in a specific region of the brain contributes to the development of anxiety and depression in response to real-life stress. Their study establishes an objective neurobiological measure for stress resilience in humans.
When the COVID-19 pandemic hit in early 2020, many families found themselves suddenly isolated together at home. A year later, new research has linked this period with a variety of large, detrimental effects on individuals' and families' well-being and functioning.
Loss of the ability to experience pleasure - or anhedonia - has been revealed as a key feature in frontotemporal dementia, in contrast to Alzheimer's disease. The findings from brain scans, believed to be a first, show grey matter deterioration in the so-called pleasure system of the brain - these regions were distinct from those implicated in depressio […]
Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.
Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a new study.
Increased consumption of flavanols - a group of molecules occurring naturally in fruit and vegetables - could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research.
A new study reveals that an evidence-based treatment may 'fix' a human short circuit that leads to anxiety and, with the help of brain imaging, might predict treatment outcomes for adolescents with anxiety disorders. Researchers say this could determine medication effectiveness more quickly to help patients.
Bullying at boarding schools has a negative impact on students' emotional health, but for male students, having a school staff member to rely on for support may mute the harmful effects of bullying, according to a new study. Support networks did not have the same effect for female students, the researchers say.
Information processing by the brain is altered in depressed individuals. A study conducted at the University of Helsinki found that in depressed patients, the processing of visual perceptions is also different.
Scientists have taken the connection between wisdom, loneliness and biology one step further, reporting that wisdom and loneliness appear to influence -- and/or be influenced by -- microbial diversity of the gut.
A recent study found that when people feel they have resolved an argument, the emotional response associated with that disagreement is significantly reduced and, in some situations, almost entirely erased.
The COVID-19 pandemic severely impacted the mental health of young people, with increased levels of clinical depression being identified, a new study reports. A decrease in alcohol consumption was also identified amongst young people during the pandemic.
A new study reports a high global prevalence of both depression and anxiety during the COVID-19 pandemic and shows how implementation of mitigation strategies including public transportation and school closures, and stay-at-home orders impacted such disorders.