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Epilepsy Research News — ScienceDaily
- Novel deep brain simulation approach for treating drug-refractory epilepsy March 6, 2023A research team proposes an innovative sequential narrow-field deep brain stimulation procedure to treat intractable epilepsy.
- The Mozart effect myth: Listening to music does not help against epilepsy March 6, 2023Over the past fifty years, there have been remarkable claims about the effects of Wolfgang Amadeus Mozart's music. Reports about alleged symptom-alleviating effects of listening to Mozart's Sonata KV448 in epilepsy attracted a lot of public attention. However, the empirical validity of the underlying scientific evidence has remained unclear. Now, p […]
- Seizures can be predicted more than 30 minutes before onset in patients with temporal lobe epilepsy March 1, 2023Seizures can be predicted more than 30 minutes before onset in patients with temporal lobe epilepsy, opening the door to a therapy using electrodes that could be activated to prevent seizures from happening, according to new research.
- Study identifies cause for mysterious cases of epilepsy in children January 12, 2023An international consortium has identified at least some of the genetic drivers of a mysterious form of pediatric epilepsy.
- Study identifies neuronal basis of impaired consciousness in 'absence' epilepsy January 10, 2023Imagine slipping in and out of consciousness hundreds of times per day, staying awake the whole time but having no sense of awareness during these lapses. In children with absence epilepsy, these highly disruptive episodes are known as absence seizures. Absence seizures can be captured by abnormal rhythms on EEG recordings, but their neuronal cause has never […]
- Can diet combined with drugs reduce seizures? January 5, 2023Following a modified Atkins diet high in fat and low in carbohydrates plus taking medication may reduce seizures in people with tough-to-treat epilepsy, according to a new study.
- Researchers discover genetic variant associated with earlier onset childhood epilepsy November 30, 2022Researchers have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies. The researchers also identified a potentially effective treatment strategy.
- New tools map seizures, improve epilepsy treatment November 29, 2022Two new models could solve a problem that's long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part of the brain. By helping surgeons decide if and where to operate, the tools could help patients avoid risky and often-ineffective surgeries as well as prolo […]
- Researchers take key step toward improving lives of people with epilepsy November 28, 2022Researchers have taken a key step toward improving the lives of patients with epilepsy by developing a sensor system for quickly testing their saliva to see if they have the correct level of anti-epileptic medicine in their system.
- Neuroscientists discover a new drug candidate for treating epilepsy November 24, 2022Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy worldwide. Although symptomatic medications are available, one-third of TLE patients remain unresponsive to current treatment, so new drug targets are critically needed. Neuroscientist have recently identified and developed a new drug candidate that has potential for effectively treatin […]
- Risk of seizures is higher after COVID-19 than after influenza, study finds November 16, 2022People who have a COVID-19 infection are more likely to develop seizures or epilepsy within the next six months than people who have an influenza infection, according to a new study.
- Children with severe form of epilepsy should receive flu vaccine due to high seizure risk after influenza infection, study finds November 15, 2022Children with a severe form of epilepsy should be vaccinated against the flu due to the high risk of seizures being triggered by an influenza infection, according to a new study.
- An animal model of West syndrome exhibits a progressive increase in epileptic spasms and learning and memory deficits November 3, 2022Researchers have provided the first demonstration of a progressive increase in epileptic spasms along with learning and memory deficits in an animal model of this disorder.
- Gene therapy targeting overactive brain cells could treat neurological disorders November 3, 2022A new treatment for neurological and psychiatric diseases, that works by reducing the excitability of overactive brain cells, has been developed.
- Do people who undergo bariatric surgery have a higher risk of epilepsy? September 29, 2022People who have had bariatric surgery may have an increased risk of developing epilepsy, according to a new study.
- AI algorithm that detects brain abnormalities could help cure epilepsy August 12, 2022An artificial intelligence (AI) algorithm that can detect subtle brain abnormalities which cause epileptic seizures has been developed.
- Brain signal irregularity may provide clues to understanding epileptic process June 14, 2022Researchers propose a new method to differentiate signals from the epileptic focus from those recorded in other parts of the brain without the presence of an epileptic seizure. This technique may help detect epilepsy-induced features from these signals much quicker than conventional analysis techniques.
- Breakthrough tech enables seizure localization in minutes May 12, 2022New research introduces a novel network analysis technology that uses minimally invasive resting state electrophysiological recordings to localize seizure onset brain regions and predict seizure outcomes in just 10 minutes.
- Antidepressant use during pregnancy not linked to epilepsy in children May 12, 2022A new study suggests that antidepressant use by mothers during the first trimester of pregnancy does not increase the chances of epilepsy and seizures in babies.
- Some shunts used after epilepsy surgery may risk brain shifting and chronic headaches May 11, 2022A new study associates some types of shunts used after epilepsy surgery with brains shifting toward the side of the skull.
Epilepsia
- A comparison of statistical versus clinical classifiers of seizure clustering in women with catamenial and noncatamenial epilepsy March 27, 2023Epilepsia, EarlyView.Andrew G. Herzog, Enrique Carrazana, Adrian L. Rabinowicz
- Disadvantage and Neurocognitive Comorbidities in Childhood Idiopathic Epilepsies March 25, 2023Epilepsia, Accepted Article.William A. Schraegle, Rebecca F. Slomowitz, Carson Gundlach, David A. Hsu, Dace N. Almane, Carl E. Stafstrom, Michael Seidenberg, Jana E. Jones, Bruce P. Hermann
- The Presence and Severity of Epilepsy Coincide with Reduced GABA and Cortical Excitatory Markers in SSADH Deficiency March 24, 2023Epilepsia, Accepted Article.Itay Tokatly Latzer, Mariarita Bertoldi, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Paul MacMullin, Daniyal Sachee, Alexander Rotenberg, Henry H. C. Lee, Deniz Aygun, Thomas Opladen, Kathrin Jeltsch, Àngels García‐Cazorla, Jean‐Baptiste Roullet, K. Michael Gibson, Phillip L. Pearl
- Treatment of NORSE/FIRES with Tocilizumab in a child and a young adult March 24, 2023Epilepsia, Accepted Article.Marie‐Laure Girardin, Thomas Flamand, Ombeline Roignot, Marie‐Therese Abi Warde, Veronique Mutschler, Paul Voulleminot, Max Guillot, Vera Dinkelacker, Anne De Saint‐Martin
- Leveraging expertise and optimizing clinical research: Initial success of a pediatric epilepsy surgery collaborative March 24, 2023Epilepsia, EarlyView.Madison M. Berl, Jennifer I. Koop, Alyssa Ailion, Donald J. Bearden, Katrina Boyer, Crystal M. Cooper, Amanda M. Decrow, Priscilla H. Duong, Patricia Espe‐Pfeifer, Marsha Gabriel, Elise Hodges, David F. Marshall, Kelly A. McNally, Andrew E. Molnar, Emily K. Olsen, Kim E. Ono, Kristina E. Patrick, Brianna M. Paul, Jonathan Romain, Leigh N. Sepeta, Rebecca L. H. Stilp, Greta N. Wilkening, Michael Zaccariello, Frank Zelko, M. Scott Perry, the PERC Surgery Workgroup, Allyson L. Alexander, Rene Andrade‐Machado, Dallas Armstrong, Kurtis Auguste, Jeffrey Bolton, Michael Ciliberto, Jason Coryell, Dewi Depositario‐Cabacar, Krista Eschbach, William D. Gaillard, Satya Gedela, Ernesto Gonzalez‐Giraldo, Zachary Grinspan, Jason Hauptman, Pradeep Javarayee, Samir Karia, Chad Mac Manuel, Ahmad Marashly, Michael J. McCormack, Nancy McNamara, Srishti Nangia, Edward John Novotny, Adam Numis, Joffre Olaya, Chima Oluigbo, Adam Ostendorf, Shilpa B. Reddy, Erin Fedak Romanowski, Debopam Samanta, Daniel Shrey, Rani Singh, Joseph Sullivan, Priya Tatachar, Lily Wong‐Kisiel
- Pentanucleotide Repeat‐Related Disorders: Genetics and Bioinformatic Discovery and Detection March 24, 2023Epilepsia, Accepted Article.Isabel Silveira, Mark F. Bennett
- Current treatment options for Familial Adult Myoclonus Epilepsy March 22, 2023Epilepsia, Accepted Article.Antonietta Coppola, Raffaele Dubbioso, Claudia Cuccurullo, Laura Licchetta, Mar Carreno, Edouard Hirsch, Leonilda Bilo
- Passive and active markers of cortical excitability in epilepsy March 22, 2023Epilepsia, EarlyView.Georgia Ramantani, M. Brandon Westover, Stephen Gliske, Johannes Sarnthein, Sridevi Sarma, Yujiang Wang, Maxime O. Baud, William C. Stacey, Erin C. Conrad
- Metyrapone abolishes spike–wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones March 22, 2023Epilepsia, EarlyView.Gabi Dezsi, Ezgi Ozturk, Georgia Harris, Cornelius Paul, Terence J. O'Brien, Nigel C. Jones
- Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study March 22, 2023Epilepsia, EarlyView.Haris Hakeem, Bshra Ali A. Alsfouk, Patrick Kwan, Martin J. Brodie, Zhibin Chen
- The etiology and mortality of new‐onset refractory status epilepticus (NORSE) in adults: A systematic review and meta‐analysis March 21, 2023Epilepsia, EarlyView.Thahesh Tharmaraja, Jamie Sin Ying Ho, Aidan Neligan, Sanjeev Rajakulendran
- Blood–brain barrier damage and new onset refractory status epilepticus: An exploratory study using dynamic contrast‐enhanced magnetic resonance imaging March 21, 2023Epilepsia, EarlyView.Huiping Li, Xian Liu, Ruihong Wang, Aili Lu, Zhaohui Ma, Shibiao Wu, Hongji Lu, Yaming Du, Kan Deng, Lixin Wang, Fang Yuan
- The need for an individualized approach to what is considered a clinically significant reduction in seizure frequency: A patient's perspective March 21, 2023Epilepsia, EarlyView.Mia L. Kop
- From basic sciences and engineering to epileptology: A translational approach March 21, 2023Epilepsia, EarlyView.Elie Bou Assi, Kaspar Schindler, Christophe Bézenac, Timothy Denison, Sharanya Desai, Simon S. Keller, Émile Lemoine, Abbas Rahimi, Mahsa Shoaran, Christian Rummel
- Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R‐associated proteins and downstream pathways March 20, 2023Epilepsia, EarlyView.Carlos A. Lafourcade, Fraser T. Sparks, Angelique Bordey, Ursula Wyneken, Michael H. Mohammadi
- Stimulation better targets fast‐ripple generating networks in super responders to the responsive neurostimulator system March 20, 2023Epilepsia, EarlyView.Shennan Aibel Weiss, Dawn Eliashiv, John Stern, Daniel Rubinstein, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Jerome Engel, Richard Staba, Michael R. Sperling
- Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy March 20, 2023Epilepsia, EarlyView.Georgia Ramantani, Christine Bulteau, Dorottya Cserpan, Willem M. Otte, Georg Dorfmüller, J. Helen Cross, Josef Zentner, Martin Tisdall, Kees P. J. Braun
- Resting state functional connectivity demonstrates increased segregation in bilateral temporal lobe epilepsy March 20, 2023Epilepsia, EarlyView.Alfredo Lucas, Eli J. Cornblath, Nishant Sinha, Peter Hadar, Lorenzo Caciagli, Simon S. Keller, Leonardo Bonilha, Russell T. Shinohara, Joel M. Stein, Sandhitsu Das, Ezequiel Gleichgerrcht, Kathryn A. Davis
- The fascinating phenotypic spectrum of SCN1A gain‐of‐function epilepsies March 20, 2023Epilepsia, EarlyView.Ingrid E. Scheffer
- Identification of patients with epilepsy using automated electronic health records phenotyping March 19, 2023Epilepsia, Accepted Article.Marta Fernandes, Aidan Cardall, Jin Jing, Wendong Ge, Lidia M. V. R. Moura, Claire Jacobs, Christopher McGraw, Sahar F. Zafar, M. Brandon Westover
Mental Health Research News — ScienceDaily
- Study finds worrying about election stress can harm your health -- and what you can do about it March 22, 2023New research finds that simply anticipating stress related to political elections causes adverse physical health effects. However, the study also finds there is something people can do to mitigate those negative health effects.
- Researchers find strong adolescent-parent relationships lead to better long-term health outcomes in young adults March 21, 2023Researchers have found that adolescents who report strong relationships with their parents have better long-term health outcomes. Study findings suggest that investments in improving parent--adolescent relationships could help improve general health, mental health and sexual, health while also reducing substance use in young adulthood.
- New evidence: Immune system cells in the gut linked to stress-induced depression March 20, 2023In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression. Targeting changes mediated by these immune cells in the gut, with drugs or other thera […]
- COVID-19 pandemic has long-lasting effects on adolescent mental health and substance use March 14, 2023The COVID-19 pandemic has had a long-lasting impact on adolescent mental health and substance use, according to a new population-based study based on survey responses from a sample of over 64,000 13- to 18-year-olds assessed prior to and up to two years into the pandemic.
- 'All work, no independent play' cause of children's declining mental health March 9, 2023A new study suggests the rise in mental health disorders in children and teens is attributed to a decline over decades in opportunities for them to play, roam and engage in activities independent of direct oversight and control by adults. Although well intended, adults' drive to guide and protect children has deprived them of the independence they need […]
- Hunter-gatherer childhoods may offer clues to improving education and wellbeing in developed countries March 8, 2023Hunter-gatherers can help us understand the conditions that children may be psychologically adapted to because we lived as hunter-gatherers for 95% of our evolutionary history. And paying greater attention to hunter-gatherer childhoods may help economically developed countries improve education and wellbeing.
- Researchers develop blood test for anxiety March 7, 2023Researchers have successfully developed a blood test for anxiety. The test examines biomarkers that can help them objectively determine someone’s risk for developing anxiety, the severity of their current anxiety and which therapies would likely treat their anxiety the best.
- Adding antipsychotic med to antidepressant may help older adults with treatment-resistant depression March 3, 2023For older adults with clinical depression that has not responded to standard treatments, adding the drug aripiprazole to an antidepressant they're already taking is more effective than switching from one antidepressant to another, according to a new multicenter study.
- Lending a paw for defense veterans: 'Clear evidence' that assistance dogs help improve mental health March 1, 2023A new study focused on defense veterans' mental health has found strong evidence that assistance dogs used in conjunction with traditional therapies provide the most effective treatment outcomes.
- Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders February 27, 2023A new brain connection can explain how early-life stress and adversity trigger disrupted operation of the brain's reward circuit, offering a new therapeutic target for treating mental illness. Impaired function of this circuit is thought to underlie several major disorders, such as depression, substance abuse and excessive risk-taking.
- Being flexible is key to protecting mental wellbeing in people with chronic pain February 27, 2023Research has found the biggest threat to the mental health of people living with chronic pain isn't necessarily how intense their pain is, but the extent to which it interferes with their daily life.
- The far-reaching consequences of child abuse February 24, 2023Adverse childhood experiences in mothers can affect their children's mental and physical health, as researchers report. The study found that maltreatment during a mother's childhood is associated with a higher risk of health problems such as asthma, autism, and depression in the next generation. Early intervention to support affected mothers might […]
- Exercise more effective than medicines to manage mental health, study shows February 24, 2023Researchers are calling for exercise to be a mainstay approach for managing depression as a new study shows that physical activity is 1.5 times more effective than counseling or the leading medications.
- Reducing social media use significantly improves body image in teens, young adults February 23, 2023Teens and young adults who reduced their social media use by 50% for just a few weeks saw significant improvement in how they felt about both their weight and their overall appearance compared with peers who maintained consistent levels of social media use, according to new research.
- Dynamic expression of brain serotonin receptors across the menstrual cycle provides clues about premenstrual dysphoric disorder February 23, 2023A new study explores the interplay between the serotonin system and estradiol in the brain, showing that the central nervous system in patients with premenstrual dysphoric disorder (PMDD) seems to increase serotonin transporter density from the periovulatory phase (when estradiol levels are high) to premenstrual cycle phase (when both estradiol and progester […]
- Psychological stress impedes performance, even for Olympic athletes February 16, 2023Analysis of archers' biometric data during the 2020 Tokyo Olympics provides empirical support for something sports fans have long suspected.
- Psychostimulants: Cause of differences in duration and intensity of effect explored February 15, 2023Psychostimulants interacting with the dopamine transporter are found in the therapy of neuro-psychiatric disorders, such as ADHD or depression, as well as on the illicit drug market. In order to better understand their exact mode of action and undesirable effects, a research team has been working on the question of why different substances in this group of s […]
- Researchers link 27 genetic variants to ADHD February 9, 2023A large international study has identified 27 loci in the human genome with genetic variants that increase the risk of ADHD. This is more than twice as many as previous studies have found.
- Warning signs of poor mental health in athletes February 8, 2023'Put down' language is a key indicator of poor mental health in athletes, recent research shows. More than 400 athletes across a variety of sports, ages and levels of experience were questioned for the study by sports psychology experts.
- Researchers find a link between traffic noise and tinnitus February 3, 2023There is a correlation between traffic noise and risk of developing tinnitus, researchers have found. They point to a vicious cycle involving stress reactions and sleep disturbance as a potential cause. If you live near a busy road, it may increase your stress levels and affect your sleep. When we are under stress and sleep poorly, we may be at a higher risk […]
Tacking on the Styx 